Advanced Parkinson’s

Key Botanical Components and Mechanisms

Nymphaea caerulea (blue lotus)

Rich in aporphine alkaloids, Nymphaea caerulea may modulate dopaminergic receptors and calm central nervous system hyperactivity. It contributes mild euphoria, reduces oxidative burden, and supports mental clarity in PD-associated fatigue and depression.

Schisandra chinensis (schisandra berry)

The lignans in Schisandra chinensis promote mitochondrial integrity, reduce neuroinflammation, and regulate stress hormones via the HPA axis. It has been studied for its role in cognitive endurance and adaptation to oxidative load.

Mentha spicata (spearmint leaf)

Aromatic monoterpenes in Mentha spicata (e.g., carvone) display anti-inflammatory and mucosal immune-modulating activity. It supports neuroimmune signaling, enhances breath quality, and may help modulate gastrointestinal absorption pathways.

Syzygium aromaticum (clove)

Containing eugenol, Syzygium aromaticum offers broad-spectrum antiviral, antioxidant, and anti-inflammatory effects. It complements schisandra and spearmint by stabilizing inflammatory cytokine cascades, particularly in neurovascular interfaces.

Quercetin (flavonoid extract)

Quercetin is a well-studied flavonol with capacity to inhibit viral entry and replication, suppress TNF-α and IL-6, and preserve mitochondrial function. Its inclusion is essential for countering post-viral neuroinflammatory loops and promoting antioxidant balance.

Cinchona spp. (cinchona tree bark)

Alkaloids from Cinchona spp., including quinine, interfere with viral replication and endosomal acidification. These mechanisms have relevance in treating post-viral syndromes and neurotropic viral persistence.

Rosa damascena (rose petals)

Polyphenols from Rosa damascena downregulate IL-1β and other inflammatory mediators. Rose also provides gentle emotional stabilization, making it ideal for neurodegenerative patients experiencing stress, grief, or agitation.

Allium cepa (green onions)

Organosulfur compounds in Allium cepa inhibit NF-κB and COX-2 pathways, contributing to systemic anti-inflammatory tone. It also supports blood–brain barrier integrity and vascular antioxidant defense.

Citrus x meyeri and Citrus x latifolia (lemons, limes)

These citrus fruits deliver vitamin C and flavonoids that enhance quercetin uptake and exhibit synergistic antiviral effects. They also promote liver detoxification and circulatory balance.

Sesamum indicum (white sesame seeds)

A nutrient-dense source of lignans, sterols, and vitamin E, Sesamum indicum supports neuronal membrane stability, modulates lipid peroxidation, and aids in neurotransmitter regulation.

Solvent System

Non-GMO French Vodka (40% ethanol): Provides a stable, broad-spectrum extraction medium for both polar and non-polar compounds. The ethanol base ensures long-term phytochemical integrity and enhanced cellular uptake.

Summary

The Advanced Parkinson’s Tincture combines time-tested medicinal plants with flavonoid antioxidants and adaptogenic support. It is designed to address neuroimmune dysregulation, oxidative mitochondrial burden, and viral post-infection syndromes common in Parkinson’s Disease progression. This formulation offers an integrated approach to symptom management and disease modulation by targeting inflammation, neural metabolism, and emotional resilience.

Basis for Antiviral and Neuroprotective Activity

1. Synergistic Antiviral Mechanisms

Quercetin + Citrus x latifolia, Citrus x meyeri (lime, lemon)

Flavonoids from both sources are known to block viral entry and replication while enhancing cellular antioxidant defenses. When combined, they exhibit synergistic effects by targeting multiple stages of the viral life cycle (Colunga Biancatelli et al., 2020; Kim et al., 2010).

Cinchona spp. (chinchona bark) + quercetin

Alkaloids from Cinchona spp. (e.g., quinine) inhibit viral replication through endosomal disruption, complementing quercetin’s inhibition of viral polymerase. This combination broadens the antiviral spectrum to both enveloped and non-enveloped viruses (Paton et al., 2021).

Syzygium aromaticum (clove) + Mentha spicata (spearmint)

Eugenol and carvone disrupt viral lipid membranes and inhibit pro-inflammatory cytokine production. Together, they enhance local mucosal immunity and exhibit broad-spectrum virucidal effects (Benencia & Courrèges, 2000).

2. Neuroimmune Modulation and Anti-inflammatory Synergy

Schisandra chinensis (schisandra berry) + Rosa damascena (rose petals)

Lignans from Schisandra chinensis modulate neuroimmune responses and protect mitochondria from oxidative damage, while polyphenols in Rosa damascena suppress inflammatory cytokines. Their combination may reduce microglial overactivation linked to neurodegeneration (Liu et al., 2017; Naz et al., 2022).

Allium cepa (green onions) + Syzygium aromaticum (cloves)

Organosulfur compounds from Allium cepa and eugenol from Syzygium aromaticum inhibit NF-κB and COX-2 pathways. Their synergistic action may limit neuroinflammation and blood–brain barrier permeability disruptions common in PD (Zhou et al., 2016; Chatterjee et al., 2007).

3. Mitochondrial and Cognitive Support

Nymphaea caerulea (blue lotus) + Schisandra chinensis (schisandra)

Alkaloids from Nymphaea caerulea may act on dopaminergic receptors, while Schisandra chinensis supports mitochondrial resilience. Together, they could maintain neural activity and reduce fatigue-related symptoms in advanced PD (Gamage et al., 2019; Panossian et al., 2008).

4. Broad Implications for Viral-Triggered PD

Post-viral parkinsonism has been historically observed, including after the 1918 influenza pandemic and more recently with COVID-19. Plant-derived antivirals and immune modulators may reduce viral persistence in neural tissues and inhibit the chronic inflammation that accelerates dopaminergic neuron loss (Takahashi et al., 2020; Sulzer et al., 2020).

Conclusion

The selected botanical ingredients present a multifaceted, synergistic approach to neuroimmune regulation and viral suppression. Evidence supports their potential to mitigate mechanisms central to Parkinson’s pathology, particularly where viral triggers are involved. Further study in integrative neuroprotection and virology is warranted.

What You Can Do To Support Your Body

Advanced Neural Formula

Goal: Support comfort, antioxidant status, and daily function.

Diet:

• Fruits: Blueberries, kiwi, ripe bananas (if tolerated)

• Vegetables: Leafy greens, steamed root vegetables (carrot, beet), squash

• Herbs/Spices: Turmeric, ginger, mild rosemary

• Fungi: Lion’s mane, reishi (teas)

• Minerals: Magnesium (greens, nuts), potassium (beans, squash)

• Beverages: Calming herbal teas (chamomile, lemon balm), ample water

Lifestyle: Gentle mobility, stretching, massage, fall-prevention strategies, hydration, and consistent meals.

Why diet matters: Antioxidant-rich, easy-to-digest meals help maintain daily comfort and energy, complementing the tincture’s supportive approach.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

References

Benencia, F. and Courrèges, M.C., 2000. In vitro and in vivo activity of eugenol on human herpesvirus. Phytotherapy Research, 14(7), pp.495–500.

Chatterjee, S. et al., 2007. Eugenol and its role in chronic inflammation and cancer: bioavailability and therapeutic implications. Inflammopharmacology, 15(6), pp.255–264.

Colunga Biancatelli, R.M.L. et al., 2020. Quercetin and vitamin C: synergistic therapy for the prevention and treatment of COVID-19. Frontiers in Immunology, 11, p.1451.

Gamage, M.M. et al., 2019. Apomorphine-like dopaminergic potential of alkaloids from Nymphaea caerulea. Journal of Ethnopharmacology, 234, pp.1–10.

Kim, Y. et al., 2010. Quercetin inhibits influenza A virus entry. Viruses, 2(12), pp.2626–2638.

Liu, G.T. et al., 2017. Neuroprotective effects of Schisandra chinensis against neuroinflammation. Neurochemistry International, 104, pp.1–9.

Naz, S. et al., 2022. Anti-inflammatory potential of Rosa damascena: a review. BMC Complementary Medicine and Therapies, 22(1), pp.1–12.

Panossian, A., Wikman, G. and Sarris, J., 2008. Adaptogens in mental and behavioral disorders. Psychiatric Clinics, 31(1), pp.49–64.

Paton, N.I. et al., 2021. Quinine in the treatment of COVID-19 and other viral infections: a review. Drug Development Research, 82(7), pp.842–850.

Sulzer, D. et al., 2020. COVID-19 and possible links with Parkinson’s disease. JAMA Neurology, 77(12), pp.1480–1481.

Takahashi, T. et al., 2020. SARS-CoV-2 and Parkinsonism: potential links and research directions. Movement Disorders, 35(12), pp.1797–1799.

Zhou, H. et al., 2016. Anti-inflammatory effects of sulfur compounds from Allium cepa. Molecular Nutrition & Food Research, 60(7), pp.1502–1512.